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The Jenny Lab

Department of
Developmental and Molecular Biology at

Albert Einstein

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Science at the Heart of Medicine
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Research

 

Our interest is to understand how cells become polarized and a tissue is patterned. In particular, how do cells differentiate and interpret polarizing cues to become asymmetric, and what regulatory mechanisms ensure the precise development of a living organism? Aberrations in patterning – be it polarization or growth control – lead to severe birth defects and diseases such as cancer. The signaling pathways that control patterning of a fly are also affected in abnormal behavior of human cells.

We recently also became interested to assess the existence of Chaperone Mediated Atuophagy (CMA), a selective form of autophaagy in Drosophila.

Our lab combines the powerful biochemical and genetic approaches offered by the Drosophila model system to elucidate the fundamental biological mechanisms and we have ongoing collaborations with several other labs to translate our findings into vertebrate systems.

Read more by selecting the links on the right:


Image 1
PCP signaling and the cytoskeleton
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Image 2
Wnk in Wnt signaling
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Image 2
CMA project
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